Etiology and Pathogenesis.
—According to Toomey,265 the portal of entry for the virus of poliomyelitis is by way of the gastrointestinal tract rather than by the olfactory bulb. In reviewing histories of affected persons, the author noticed that they usually had some symptom referable to the gastrointestinal tract. An early sign was paralysis of the gastrointestinal tract and commonly paralysis of the bladder. These symptoms were noted long prior to the development of somatic paralysis of the periphery. Monkeys were used for experimental work. The urinary flow was blocked in 6 animals by the production of uroliths with sulfonamide drugs. In 6 animals the virus was injected intracerebrally. In those receiving the drug urinary retention developed, and they showed symptoms of the disease three or four days before the control animals. The same type of animal was used to show that the disease could be produced by way of
IRWIN CE. PROGRESS IN ORTHOPEDIC SURGERY FOR 1945 A Review Prepared by an Editorial Board of the American Academy of Orthopaedic SurgeonsX. INFANTILE PARALYSIS. Arch Surg. 1947;54(4):445-458. doi:10.1001/archsurg.1947.01230070453008