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Article
July 1949

EFFECT OF APPLICATION OF SEVERAL ANTIBACTERIAL SUBSTANCES ON HEALING OF WOUNDS

Author Affiliations

DETROIT
From the Division of General Surgery of the Henry Ford Hospital.

Arch Surg. 1949;59(1):57-61. doi:10.1001/archsurg.1949.01240040060003
Abstract

IN SEVERAL previous communications from this laboratory,1 there have been presented the results of simple animal experiments to determine the effect of the topical application of various agents on the healing of wounds. We have observed the healing of two symmetric cutaneous defects on the abdominal wall of the guinea pig; one of these wounds was treated with the test substance while the other served as a control. This type of experiment appears to be a reliable indicator of the response which may be expected from human tissue. For example, a number of substances recommended for the treatment of burns were tested.1b Among these was tannic acid, which produced a conspicuous delay in healing. This experimental finding has had ample clinical confirmation. Many other agents have failed to show the stimulating effect claimed by their sponsors. This paper presents the results of experiments on wound healing with five

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