THE FAILURE of bilateral supradiaphragmatic vagotomy to protect against the development of ulcer in the Mann-Williamson dog, as recently reported,1 has been the stimulus for the work herein described. This investigation was conducted to determine (1) the effect of total gastrectomy with diversion of the duodenal secretions into the terminal portion of the ileum on the development of ulcer and (2) to determine the possible existence of another factor besides the role of acid in the formation of ulcer in man.
The role of acid in the production of ulcer appears to be too definite2 to be disputed, and it is also well known that vagotomy produces in the dog a definite decrease in the amount of acid and in the total volume of gastric secretion.3 However, the failure of vagotomy to protect against the development of ulcer in the Mann-Williamson dog led my colleagues and me
OLIVER JV. EFFECT OF GASTRECTOMY AND DIVERSION OF DUODENAL SECRETIONS INTO THE TERMINAL PORTION OF THE ILEUM ON DEVELOPMENT OF ULCER. Arch Surg. 1949;59(2):199-209. doi:10.1001/archsurg.1949.01240040204003