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Article
August 1949

INCREASE OF SERUM LIPASE IN EXPERIMENTALLY INDUCED APPENDICAL PERITONITIS

Author Affiliations

PHILADELPHIA
From the Harrison Department of Surgical Research, School of Medicine, and the Graduate School of Medicine, University of Pennsylvania.

Arch Surg. 1949;59(2):337-347. doi:10.1001/archsurg.1949.01240040342015
Abstract

THE USE of determinations of serum amylase and serum lipase in the diagnosis of diseases involving the pancreas has achieved great prominence during the past ten years.1 Increases of serum amylase have been reported in cases of acute pancreatitis,2 perforation of peptic ulcer into or near the pancreas3 and trauma to the pancreas.4 High transient increases have been obtained experimentally in cases of complete obstruction of the pancreatic ducts.5 and a continued increase for over a year following permanent closure of the ducts has been reported.6 Hyperamylasemia has also been observed in diseases of the salivary glands such as mumps,7 although here also some investigators have ascribed the increase to transient pancreatitis.8 The mass of evidence at hand,7b,c however, would indicate that the high amylase level in cases of mumps occurs most frequently without evidence of involvement of the pancreas.

The

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