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Article
April 1950

SYNTHETIC ADHESIVES—A NEW HEMOSTATIC AGENTA Third Report

Author Affiliations

BEVERLY HILLS, CALIF.
From the Department of Experimental Medicine, University of Southern California School of Medicine.

Arch Surg. 1950;60(4):793-805. doi:10.1001/archsurg.1950.01250010814016
Abstract

INVESTIGATIONS begun in September 1943 (Lowry1) demonstrated the practicability of controlling bleeding in abdominal viscera in animals by the application of synthetic adhesives. A large percentage of rabbits in these early experiments made uneventful recoveries after pie-shaped sections of their livers had been freshly extirpated and the ensuing gap enclosed with analogues of scotch tape.® Animals reoperated on at various intervals in which a cellophane-Buna S adhesive was used showed a considerable amount of surrounding tissue reaction, but tapes composed of a synthetic resin facing on a polyvinyl alcohol film, while not completely absorbed, were found to cause very little tissue reaction. The polyvinyl alcohol-synthetic resin combination also appeared most effective in controlling bleeding.

A more detailed study (Lowry2) in which polyvinyl alcohol film and synthetic resins (acrylic esters) were implanted separately within the liver, spleen, abdomen and subcutaneous tissues of a large number of rats, mice and

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