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October 1950

EFFECT OF BETA IRRADIATION ON GASTRIC ACIDITY

Author Affiliations

RED WING, MINN.
From the Interstate Clinic (Dr. Hedin and Dr. Miller) and the Central Research Laboratories, Inc. (Dr. Jelatis).

AMA Arch Surg. 1950;61(4):748-757. doi:10.1001/archsurg.1950.01250020754015
Abstract

THIS PAPER is a preliminary report of studies still in progress on the reduction of gastric acidity in the dog by the use of radioactive phosphorus, known as P32. The basic purpose is to determine whether beta irradiation from P32 might be effectively and safely used in the treatment of peptic ulcer by reducing gastric secretion.

Several workers1 have produced a decrease in acidity for varying intervals with the use of gamma rays. Palmer and Templeton2 in 1934 reported 100 cases of peptic ulcer treated with roentgen rays in which they irradiated the stomach anteriorly and posteriorly over a period of ten to twelve days. They reported a definite decrease in gastric acidity, which varied in extent and duration.

In 1942 two New Zealand investigators, Jenkins and McGeorge,3 using gamma rays, placed radium needles in a rubber-covered tube and passed it into the stomach under

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