KUNDRAT in 1813 was the first to give a clear description of the disease known as lymphosarcoma and thus separate it from the large and heterogenous group of lymphomas. He recognized it as a more or less widespread growth arising either from a group of lymph glands (rarely from a single one) or from a tract of lymphoid tissue such as occurs in the intestinal wall or the pharynx. MacCallum1 described it as a delicate reticulum in the meshes of which lie cells of a lymphoid character. It fails to respect the capsules of lymph glands but grows rapidly and invades and infiltrates adjacent tissues. Isolated metastasis in distant organs is rare, but the adjacent lymph glands may be involved; otherwise the growth tends to spread in loose tissue and in film or plate form over serous surfaces.
Boyd2 attempted to divide the cases into a number of
WEISSMAN I, CHRISTIE JM. PRIMARY LYMPHOSARCOMA OF THE LUNGReport of a Case. AMA Arch Surg. 1951;62(1):129-133. doi:10.1001/archsurg.1951.01250030132015