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Article
May 1951

SIGNIFICANCE OF POSTOPERATIVE GLYCOSURIA AND KETONURIA IN NONDIABETIC ADULTS

Author Affiliations

ST. LOUIS
From the Washington University School of Medicine, Department of Surgery, and Barnes Hospital.

AMA Arch Surg. 1951;62(5):683-697. doi:10.1001/archsurg.1951.01250030693010
Abstract

EVEN though glycosuria and acetonuria are fairly common after operation, their exact significance is not generally known. Do they mean a serious disturbance in carbohydrate metabolism? Is the excretion of ketone bodies evidence of a transient overproduction thereof by the liver or of diminished utilization by peripheral tissue? Is the glycosuria the result of a diminution of peripheral utilization of glucose or of increased glycogenolysis? A number of surgical patients were observed in whom quantitative determinations of the 24 hour output of glucose and of acetone were made in an attempt to answer these questions. A few of these observations were briefly reported in a previous paper from this laboratory.1

PREVIOUS WORK  In an exhaustive report published in 1933, Roscher2 studied and reviewed postoperative acidosis and ketonuria. A disturbance in acid-base balance was common, particularly in patients operated on under general anesthesia. A fall in the pH and

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