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October 1951

RADIOACTIVE ISOTOPES IN LOCALIZATION OF INTRACRANIAL LESIONSA Survey of Various Types of Isotopes and "Tagged Compounds" Useful in the Diagnosis and Localization of Intracranial Lesions with Special Reference to the Use of Radioactive Iodine-Tagged Human Serum Albumin

Author Affiliations

Department of Surgery, University of Minnesota Medical School.

AMA Arch Surg. 1951;63(4):554-560. doi:10.1001/archsurg.1951.01250040564017

DURING the last three years, a new method for diagnosis and localization of intracranial lesions has been developed.1 This method involves the use of radioactive isotopes or compounds tagged with a radioactive isotope, which when given to the patient are taken up preferentially by intracranial lesions. When the calvarium is monitored with a Geiger-Müller counter, a focus of high uptake designating a certain pathological process involving that part of the brain can be obtained. Thus, it is possible to locate the lesion in a majority of patients.

For many years, it has been known that the central nervous system possesses a peculiar defense mechanism, the so-called blood-brain barrier (B. B. B.), which protects the system by preventing toxic substances from getting into the nervous tissue. For example, in jaundiced patients, tissues other than that of the central nervous system may be highly tinged with bile pigments; the nervous tissue

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