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December 1951

TOCOPHEROLS IN TREATMENT OF PRIMARY FIBROSITISIncluding Dupuytren's Contracture, Periarthritis of the Shoulders, and Peyronie's Disease

Author Affiliations

Dr. Steinberg is Director of the Arthritis Clinic, Associate Chief of Medicine, Rochester General Hospital.

AMA Arch Surg. 1951;63(6):824-833. doi:10.1001/archsurg.1951.01250040840013

CONTINUED observations over the past decade of the clinical value of the tocopherols (vitamin E) in the treatment of primary fibrositis have yielded sufficient promising results to warrant a review at the present time. Thomson,1 in commenting on this subject, wrote the following sentence: "In fact, the general response has been so good that to assert that vitamin E has a specific effect on Dupuytren's contracture does not appear to be unduly reckless."

The results reported by Thomson concerned cases of Dupuytren's contracture involving 22 hands that were treated with vitamin E. All patients except one were treated with ephynal, 4 (50 mg.) tablets being the daily dose. The duration of the period of treatment varied from 12 to 20 weeks. The majority were treated for 20 weeks. He divided the severity of the Dupuytren contracture into Groups A, B, and C. Group A consisted of the early cases

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