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Article
June 1952

USE OF STREPTOKINASE-STREPTODORNASE (VARIDASE®) TO LYSE CLOTTED BLOOD OBSTRUCTING BILIARY DRAINAGEObstruction Following Cholecystectomy and Choledochotomy

Author Affiliations

NEW YORK
From the Department of Surgery, St. Vincent's Hospital, and New York University College of Medicine.

AMA Arch Surg. 1952;64(6):741-744. doi:10.1001/archsurg.1952.01260010761002
Abstract

THE OBJECT of this report is to demonstrate a clinical use for the fibrinolytic properties of streptokinase-streptodornase (varidase®) in the dissolution of clotted blood obstructing the postoperative drainage of the common duct following cholecystectomy and choledochotomy.

REPORT OF A CASE  A 57-year-old white woman was admitted to St. Vincent's Hospital on June 5, 1951, with a chief complaint of epigastric pain, chills, and sore throat of three days' duration.In the initial interview the patient related that she had had recurrent episodes of upper abdominal pain associated with nausea and vomiting during the past 10 years. These symptoms were occasionally brought on or aggravated by fatty or fried foods. She did not recall having clay-colored stools, dark urine, or jaundice. The relevant past history included the statement that she had had a "malignant breast tumor" 12 years previously for which a radical mastectomy had been performed. Upon admission physical examination

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