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Article
February 1953

POTASSIUM DEPLETION IN DOGSEffect on Wound Healing, on Blood Protein and Electrolyte Levels, and on Response to Anesthesia

Author Affiliations

MEMPHIS; PHILADELPHIA
From the Harrison Department of Surgical Research, the University of Pennsylvania School of Medicine, Philadelphia.

AMA Arch Surg. 1953;66(2):226-231. doi:10.1001/archsurg.1953.01260030239013
Abstract

THE HEALING of wounds may be influenced by the serum protein level,1 dehydration,2 edema, local temperature,3 acidosis,4 and deficiencies of certain vitamins.5 The purpose of the present study has been to examine the effect of potassium depletion on wound healing. As the principal intracellular cation, potassium should have an important role in the fabrication of body tissue. Measurements of other plasma electrolytes have also been made.

METHODS  Mongrel dogs were weighed, given distemper injections, and later dewormed. After the animals had survived three weeks under observation, serum sodium and potassium levels were measured with the flame photometer,6 serum carbon-dioxide-combining power was measured by the method of Van Slyke,7 and serum chloride levels were measured with a modification of the Volhard method.8 Serum protein concentration was determined by the falling drop method of Barbour and Hamilton.9 Arterial blood was used, and the

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