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Article
August 1953

USE OF BISHYDROXYCOUMARIN (DICUMAROL) FOR PREVENTION OF POSTOPERATIVE THROMBOEMBOLISMA Study of Twenty-Seven Hundred Consecutive Surgical Patients

Author Affiliations

BUFFALO
From the Department of Surgery of the Buffalo General Hospital and the University of Buffalo School of Medicine.

AMA Arch Surg. 1953;67(2):142-152. doi:10.1001/archsurg.1953.01260040147004
Abstract

THROMBOEMBOLISM is a disorder of the normal circulation of the blood which results in complete or partial obstruction of large vessels and may or may not result in detachment of a portion of the thrombus with its lodgment at another site. Thrombosis due to intravascular clotting of the circulating blood may occur in any portion of the circulatory system. Venous thrombosis, with which we are most concerned in this study, occurs most prominently in the veins of the lower extremities; in the veins of the pelvis, including the parauterine and paraprostatic veins, and occasionally in the veins of the upper extremities.

The entity of intravascular thrombosis has been recognized since the time of Hippocrates and Galen. Virchow, in 1846, was one of the earliest authors to advance the theory and demonstrate that pulmonary emboli arose from thrombi in the pelvic or femoral veins. Early in the 20th century repeated reports

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