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Article
October 1953

EXPERIMENTAL SUBPHRENIC ABSCESS

Author Affiliations

BALTIMORE
Assistant in Surgery, Sinai Hospital (Dr. Hoffman).; From the Department of Surgery and the Crockin Research Laboratory, Department of Laboratories, Sinai Hospital.

AMA Arch Surg. 1953;67(4):540-548. doi:10.1001/archsurg.1953.01260040549008
Abstract

A COMPLETE review of the literature revealed no reported experimental method for the production of subphrenic abscesses. A predictable standardized method would be valuable in studying the treatment and natural history of such a condition. It would be a great aid in the experimental evaluation of the role of surgery, in conjunction with the antibiotic and chemotherapeutic agents, in the treatment of subphrenic abscesses. It was with these aims in mind that the following study was carried out.

MATERIALS AND METHODS  The abscesses were produced in healthy, adult, male rabbits. The basic principle utilized was the fact that a gauze sponge, when placed in the peritoneal cavity of animals or of human beings produces a granulomatous reaction, with the sponge encapsulated in its center. It was felt that the most logical procedure would be to insert a gauze sponge in the subdiaphragmatic space at one operation, allow time for the

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