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Article
November 1953

AN INVESTIGATION OF EFOCAINE, A LONG-ACTING LOCAL ANESTHETIC AGENTII. Clinical Studies

Author Affiliations

DURHAM, N. C.
From the Division of Anesthesiology and the Department of Pathology, Duke University School of Medicine and Hospital.

AMA Arch Surg. 1953;67(5):731-737. doi:10.1001/archsurg.1953.01260040742010
Abstract

IN THE preceding paper,1 a description is given of the chemical nature and theoretical mode of action of Efocaine. The anatomical effects of this material on animal tissues are described in detail. This paper reports concurrent clinical studies.

Since its introduction, Efocaine has been used by numerous anesthetists and surgeons with apparent satisfactory results. The use of this agent in anorectal and perineal surgery was reported by Tucker,2 Gross and Shaftel,3 and Cappe and Pallin.4 These authors concluded that Efocaine is a safe and effective agent for control of postoperative pain. This drug has been advocated for inducing intercostal blocks to control pain and prevent pulmonary complications in patients having thoracic and upper abdominal surgery. After clinical trial, Deaton and Bradshaw,5 Deaton,6 and Puderback and Shaftel7 recommended its use. Iason and Shaftel,8 Bartlett and Eastwood,9 and Roualle10 reported results of

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