[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.176.30. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1954

EFFECT OF STREPTOKINASE-STREPTODORNASE ON PERITONEAL TALC ADHESIONS AND GRANULOMASExperimental Study

Author Affiliations

JERUSALEM, ISRAEL
From the Departments of Surgery and Pathology, Hadassah University Hospital, and the Hebrew University-Hadassah Medical School.

AMA Arch Surg. 1954;68(1):69-75. doi:10.1001/archsurg.1954.01260050071009
Abstract

STREPTOKINASE-streptodornase mixtures (Sk-Sd) have been used in a variety of clinical conditions characterized by the presence of purulent exudates or coagulated blood. The results obtained by local application or by instillation have been favorable in thoracic empyema, hemothorax and pleural effusions,* gangrene of the extremities,9 infected sinus tracts,† osteomyelitis,9 tuberculous meningitis and adenitis,‡ burns,16 and miscellaneous soft tissue infections.§ The data suggest that streptokinase-streptodornase mixtures exert a double action. The streptokinase, in the presence of a serum component, lyses fibrin.∥ The streptodornase depolymerizes desoxyribonucleoprotein which accumulates in purulent exudates from the nuclei of dead cells.¶ The final result is a liquefaction of purulent or clotted material which is readily removed.

The present experiments were initiated to study the effects of Sk-Sd on peritoneal adhesions. It was assumed that these enzymes liquefy fibrinous and nucleoprotein exudates and, thus, that they might prevent peritoneal adhesions which develop from such

First Page Preview View Large
First page PDF preview
First page PDF preview
×