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Article
April 1954

NEW METHOD FOR DETERMINATION OF GALL-BLADDER FUNCTION

Author Affiliations

LOS ANGELES
From the Surgical Service and Radioisotope Unit of the Veterans Administration Center, and the Departments of Surgery and Radiology, University of California School of Medicine at Los Angeles.

AMA Arch Surg. 1954;68(4):417-421. doi:10.1001/archsurg.1954.01260050419003
Abstract

INTRAVENOUS cholecystography is the most reliable method for evaluating function of the gall bladder. Introduced in 1924 by Graham and Cole,2 the technique rapidly came into widespread use. However, toxic side-reactions were not infrequently encountered. The subsequent introduction of oral contrast media which did not cause these undesirable reactions led to the abandonment of the intravenous technique. In 1948 Moore and his associates3 reported the successful use of iodinated fluorescein compounds for intravenous cholecystography.

It is the purpose of this report to describe the results obtained with a new intravenous method for the determination of gall-bladder function in a series of 102 patients. The method employs radioactive diiodofluorescein (DIF) as a tracer agent and the scintillation counter to detect the gamma radiation from the I131

METHOD  Radioactive diiodofluorescein was chosen as the tracer agent because it is rapidly removed from the blood stream and excreted in the

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