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Article
June 1954

METASTATIC CHORIONEPITHELIOMA OF LUNG WITH NITROGEN MUSTARD THERAPYPreliminary Report

Author Affiliations

OMAHA
From the University of Nebraska College of Medicine.

AMA Arch Surg. 1954;68(6):829-837. doi:10.1001/archsurg.1954.01260050831012
Abstract

CHORIONEPITHELIOMA, which technically should be hailed by its correct pathological appellation of choriocarcinoma, is a rare tumor of fetal origin which is highly malignant and rather bizarre in its action.

According to Novak,1 50% follow in the wake of a previously existing hydatidi-form mole; 25% arise from abortion, and 25% originate from full-term pregnancies. Ectopic gestation, as well as a few reported teratomata from various sites, has also been reported as an etiological factor.

A review of the literature, according to Mohler and McConnell,2 reveals that approximately 2,000 cases have been reported. A statistical study by Novak1 reveals an incidence of choriocarcinoma in the neighborhood of 1 in every 150,000 to 200,000 pregnancies.

Holman and Schurner,3 in a review of 107 treated cases, noted the mortality to be 15% in those cases which were postmolar, and in those resulting from the stimulation of abortion and full-term

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