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July 1954

RETROPERITONEAL METASTATIC DISEASE DUE TO CARCINOMA OF THE PROSTATEValue of Serum Prostatic Acid Phosphatase in Identifying Retroperitoneal Metastasis Originating from Carcinoma of Prostate

Author Affiliations

From the Cancer Research and Cancer Control Unit, Tufts College Medical School; Dr. Bonner, Trainee, National Cancer Institute.

AMA Arch Surg. 1954;69(1):122-124. doi:10.1001/archsurg.1954.01270010124019

THIS IS an abstract of the pertinent data of a case in which there was an unusual spread of a prostatic carcinoma that regressed after orchiectomy and estrogen therapy. The case demonstrates the diagnostic possibilities of the sensitive method used for measuring serum "prostatic" acid phosphatase,1 which showed that the "prostatic" fraction of the enzyme may be elevated to an abnormal level even when the total serum acid phosphatase, as measured by the customary King-Armstrong technique, is within the normal range.

REPORT OF A CASE  A 76-year-old man had for many years had frequency, which in the recent months prior to admission, had increased and been accompanied by extreme urgency. Five days prior to admission, acute, severe, lower abdominal pain with prostration developed. The patient was seen by his family physician. Abdominal tenderness associated with some spasticity was elicited, and an enlarged prostate that was suspiciously nodular was palpated.

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