[Skip to Content]
[Skip to Content Landing]
October 1954

ISCHEMIA OF THE LUNGPractical Applications in Segmental Resection of Pulmonary Tissue

Author Affiliations

From the Surgical Research Laboratory, Department of Surgery, The George Washington University School of Medicine. Supported by the Veterans Administration Contract, V1001-M-3210. M-3210.

AMA Arch Surg. 1954;69(4):525-529. doi:10.1001/archsurg.1954.01270040081012

THE ABILITY of an organ to withstand partial or complete ischemia not only is of academic interest but may have practical importance. Techniques of operations in certain regions, tissue transplantations, safe timing in occlusion of blood supply, and other important clinical principles may depend upon the tolerance of the organs to total or complete occlusion of the blood supply.

Interest in transplantation of homologous lung tissue led to our original experiments on the ability of the lungs to withstand interruption of the blood supply.1 The experiments were designed to determine the length of time the lung would remain viable after total occlusion of its circulation. The results of the original study were astonishing. In dogs, the blood supply of the lungs could be occluded for as long as 360 minutes with the survival of lung tissues. The Table reveals the duration of ischemia and the gross and microscopic changes.

First Page Preview View Large
First page PDF preview
First page PDF preview