The fate of skin homografts transplanted among inbred strains of mice may be governed by genetic factors similar to those which are generally accepted as determining the failure or success of tumor grafts.* Various inbred strains of mice having different coat colors were selected as donors for homografts. A difference in the color of recipients would thereby give an unquestionable contrast to the skin graft and be an aid in the determination of viability.
METHODS AND MATERIALS
Full-thickness skin, approximately 70 to 80 mg. in weight and 1 sq. cm. in area, was grafted on 168 mice 6 weeks old. The technique for grafting and the criteria for viability of transplants have been described in previous publications.† The inbred strains of mice. CBA, C3H, and C57, were originally obtained from Dr. J. Bittner ‡ and maintained in our laboratories by brother and sister matings. The hair color
WERDER AA, HARDIN CA. Importance of Hair Color to Successful Skin Transplantation. AMA Arch Surg. 1955;70(3):407-410. doi:10.1001/archsurg.1955.01270090085018