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March 1955

Importance of Hair Color to Successful Skin Transplantation

Author Affiliations

Kansas City, Kan.
From the Departments of Microbiology and Surgery, University of Kansas Medical Center.

AMA Arch Surg. 1955;70(3):407-410. doi:10.1001/archsurg.1955.01270090085018

The fate of skin homografts transplanted among inbred strains of mice may be governed by genetic factors similar to those which are generally accepted as determining the failure or success of tumor grafts.* Various inbred strains of mice having different coat colors were selected as donors for homografts. A difference in the color of recipients would thereby give an unquestionable contrast to the skin graft and be an aid in the determination of viability.

METHODS AND MATERIALS  Full-thickness skin, approximately 70 to 80 mg. in weight and 1 sq. cm. in area, was grafted on 168 mice 6 weeks old. The technique for grafting and the criteria for viability of transplants have been described in previous publications.† The inbred strains of mice. CBA, C3H, and C57, were originally obtained from Dr. J. Bittner ‡ and maintained in our laboratories by brother and sister matings. The hair color

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