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May 1955

Tolerance of the Hypothermic Normal Dog's Heart to Ventricular Fibrillation

Author Affiliations

U. S. Army
From the Division of Surgery, Army Medical Service Graduate School, and the Thoracic and Cardio-Vascular Service, Department of Surgery, Walter Reed Army Hospital, Walter Reed Army Medical Center.

AMA Arch Surg. 1955;70(5):723-728. doi:10.1001/archsurg.1955.01270110095014

Interest in hypothermia continues to enlarge, and, with demand for its increased clinical application, laboratory investigations of its effects are being pursued over an everbroadening range.* The experiments to be described in this report constitute in effect part of a control experience for current and projected researches at the Army Medical Service Graduate School. Generally the clinical use of hypothermia has been limited by the specter of ventricular fibrillation. Much has been written concerning the many factors believed to influence its occurrence, but only limited information is available concerning its significance.†

From the 53 healthy adult mongrel dogs which constitute the basis for this study we have attempted to learn something of the over-all effect of ventricular fibrillation as it occurs spontaneously at reduced levels of body temperature.

Each animal was intubated under light sodium pentobarbital anesthesia, 25 mg/kg. of body weight being employed. Artificial respiration was established at 20

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