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June 1955

Relationship of Corticotropin (ACTH) to the Healing of Gastrointestinal AnastomosesExperimental and Clinical Observations

Author Affiliations

Department of General Surgery, Henry Ford Hospital.

AMA Arch Surg. 1955;70(6):871-876. doi:10.1001/archsurg.1955.01270120079010

Several surgeons have noted that wounds in patients under treatment with corticotropin (ACTH) or cortisone heal without delay, although early experimenters * demonstrated that these agents inhibit healing. For example, Cole and his associates3 used corticotropin and cortisone in a variety of surgical conditions without encountering difficulties with wound healing. Brush, Monto, and coworkers4 treated 13 patients with thrombocytopenic purpura with corticotropin or cortisone before and after splenectomy and had no wound complications. Szilagyi and associates5 reported similar results in hyperthyroid patients prepared for thyroidectomy with corticotropin.

The warnings of Hume and Moore6 and of Zimmerman7 against the use of corticotropin and cortisone in the presence of anastomoses in the gastrointestinal tract carry considerable weight when the consequences of anastomotic breakdown are contemplated. In an effort to evaluate this problem we have reviewed the outcome of corticotropin and cortisone administration in patients in this hospital with

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