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September 1955

Pliable Plastic Aortic GraftsExperimental Comparison of a Number of Materials

Author Affiliations

From the Department of Surgery, Indiana University Medical Center. Aided by a contract between the Office of Naval Research, the United States Navy, and Indiana University and by grants from the James Whitcomb Riley Memorial Association and the Indiana Heart Association.

AMA Arch Surg. 1955;71(3):449-459. doi:10.1001/archsurg.1955.01270150143016

The search for the ideal plastic material for use as an arterial substitute is important in view of the fact that autogenous and homologous vascular grafts are not available in quantities sufficient to meet the demand. Autogenous vein grafts are suitable for reconstruction of peripheral arteries but not for bridging defects of the aorta or its bifurcation. By and large, arterial homografts have proved eminently satisfactory in human cases during a period of observation extending over a number of years. It is known that these homografts do not survive as living structures but serve as a scaffolding for the ingrowth of tissue from the host. It is also known from experimental studies that degenerative changes, such as calcification, fragmentation of the elastic tissue, and aneurysmal dilatation, take place with the passage of time. To be sure, most of the reported studies concern homografts preserved by some method other than the

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