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October 1955

Unusual Manifestations of Parathyroid Adenoma

Author Affiliations

Cincinnati; Covington, Ky.; Cincinnati
From the Departments of Surgery and Pathology, University of Cincinnati College of Medicine and the Cincinnati General Hospital, Cincinnati.

AMA Arch Surg. 1955;71(4):475-485. doi:10.1001/archsurg.1955.01270160001001

Although the clinical manifestations and pathological physiology of hyperparathyroidism are now quite well recognized and understood, the diagnosis is still frequently overlooked until the opportunity for cure has been lost. This impression is borne out by the fact that when we recently surveyed the diagnostic files of seven general hospitals in a service area embracing about 1,500,000 persons over a 15-year period, only 11 proved cases of parathyroid adenoma were found. Nine of these cases are from hospitals with which we are directly connected, and only two were collected from other sources.

Among the 11 cases 4 were discovered at autopsy and in 7 the clinical diagnosis was made during life and confirmed at operation. Only 1 of the 11 cases was recognized in connection with urinary calculus as the presenting symptom. In another case a nephrectomy had been done for a large ureteral stone with septic destruction of the

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