[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.19.31. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
October 1955

Investigations of Serum Protein Changes in Combat CasualtiesThe Systemic Response to Injury

Author Affiliations

U. S. Army; U. S. Army
The U. S. Army's Surgical Research Team in Korea of the Army Medical Service Graduate School.

AMA Arch Surg. 1955;71(4):605-611. doi:10.1001/archsurg.1955.01270160131016
Abstract

Previous studies in the disturbance of protein equilibrium following surgery and injury in man and experimental animals have shown a catabolic phase, or period of negative nitrogen balance, followed by an anabolic phase, or period of positive nitrogen balance.* The serum protein changes during the catabolic phase were described by Cuthbertson and Tompsett4 primarily as a loss of albumin and an increase in globulin. However, the procedure used was a salt precipitation technique that did not separate the a1 and a2 globulin fractions from the albumin. More recently, Hoch-Ligeti, Irvine, and Sprinkle,5 using paper-strip electrophoresis, studied the serum protein changes in a group of 45 surgical patients. Their results indicated a significant decrease in the albumin fraction and an increase in a1 and a2 globulin fractions in 80% of patients within four days following operation.

PURPOSE  The massive trauma and extensive surgical procedures experienced

First Page Preview View Large
First page PDF preview
First page PDF preview
×