Previous studies in the disturbance of protein equilibrium following surgery and injury in man and experimental animals have shown a catabolic phase, or period of negative nitrogen balance, followed by an anabolic phase, or period of positive nitrogen balance.* The serum protein changes during the catabolic phase were described by Cuthbertson and Tompsett4 primarily as a loss of albumin and an increase in globulin. However, the procedure used was a salt precipitation technique that did not separate the a1 and a2 globulin fractions from the albumin. More recently, Hoch-Ligeti, Irvine, and Sprinkle,5 using paper-strip electrophoresis, studied the serum protein changes in a group of 45 surgical patients. Their results indicated a significant decrease in the albumin fraction and an increase in a1 and a2 globulin fractions in 80% of patients within four days following operation.
The massive trauma and extensive surgical procedures experienced
FRAWLEY JP, HOWARD JM, ARTZ CP, ANDERSON P, Adams C. Investigations of Serum Protein Changes in Combat CasualtiesThe Systemic Response to Injury. AMA Arch Surg. 1955;71(4):605-611. doi:10.1001/archsurg.1955.01270160131016