Psychoses are known to result from alterations in the function of the adrenal. They are found in both the hyperfunctioning (Cushing's syndrome) and the hypofunctioning (Addison's disease) states. Dysfunction of other endocrines may at times be responsible for abnormal mentation; the thyroid was probably the first to be recognized and described.
The case histories of two patients are reported here. They are considered noteworthy because of the prominence and profundity of their psychic disturbances; both had been in institutions for mental disease, and, although both exhibited typical signs and symptoms of Cushing's syndrome, these were not recognized early in the course of the disease.
—A white Syrian woman, aged 33, entered the Brooklyn Hospital Nov. 11, 1947. The following history was obtained chiefly from her husband and mother, as her mental deterioration had progressed to a state where the obtaining of a detailed reliable account was impossible. In
HAMM FC. Adrenal Surgery for Psychoses Associated with Cushing's Syndrome. AMA Arch Surg. 1955;71(4):617-619. doi:10.1001/archsurg.1955.01270160143018