November 1955

Cathode Ray Sterilization of Bone Grafts

Author Affiliations

From the Departments of Orthopedic Surgery, The Children's Medical Center, Harvard Medical School, and Division of Laboratories and Research, The Children's Medical Center. Aided by a grant from the Playtex Park Research Institute.

AMA Arch Surg. 1955;71(5):784-789. doi:10.1001/archsurg.1955.01270170142026

The purpose of this report is to record the results of experiments in the use as grafts of homogenous bone which was irradiated by high-voltage cathode rays. Development of practical methods for the storage, without significant deterioration, of tissues for clinical use as grafts has created a demand for tissue banks, and with the establishment of these banks new procedures for sterilization and preservation are constantly being investigated. With respect to bone there are advantages and disadvantages to each of the several techniques now in use. Currently the most popular method is that of storage at − 20 to − 30 C of bone, obtained under sterile conditions, from amputations, thoracotomies, or other surgical operations. The uncertainty of occurrence of these sources of supply has led to a search for alternative methods. The use of autopsy bone, being much more easily available and offering ideal selection of specimens, presents the

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