In order to evaluate the efficacy of sodium amidotrizoate (Hypaque) 50% as a medium for use in intravenous urography, a group of 109 patients was studied.
The pharmacologic aspects of sodium amidotrizoate are described adequately in literature available from the manufacturer and will not be given here.*
In 109 consecutive patients referred to the Radiology Department of the University of California Hospital for intravenous urographic studies, sodium amidotrizoate 50% was used as the opaque medium. Blood pressure determinations were done before the examination was started. Approximately onehalf of the patients then received intravenous injections of 30 cc. of sodium amidotrizoate. For the other half of the group, the amount of medium was modified according to total body weight, i.e., those patients weighing 100 lb. (45 kg.) or less received 20 cc.; 100 to 150 lb. (45 to 68 kg.), 30 cc., and more than 150 lb. (68 kg.), 40 cc.
JONES MD, STEINBACH HL, RAPHAEL RL. Sodium Amidotrizoate (Hypaque) and Sodium Acetrizoate (Urokon)Comparison of Efficacy in Intravenous Urography. AMA Arch Surg. 1956;73(1):99-104. doi:10.1001/archsurg.1956.01280010101013