Vineberg has reported on the successful transplantation of the left internal mammary artery in the heart of dogs,* which is aimed at increasing the collateral coronary blood flow of the myocardium. The obvious implication is that the method might be applied to human beings with occlusive coronary artery disease.10 By microscopic observation and injection methods he showed that anastomoses develop between the transplanted artery and the coronary arterial tree.† This occurred in 50% to 73% of the dogs submitted to the experiment.8 Vineberg showed further that the protection afforded against acute coronary artery occlusion depends upon the size of the anastomotic channels. Thrombosis of the implanted artery developed in some of the dogs, and this tended to diminish the caliber of the anastomotic vessels. By this method 69% of the dogs did not develop infarcts after acute occlusion of the anterior descending branch of the left coronary artery.
MANIGLIA R, BAKST AA. Implantation of the Left Internal Mammary Artery in the MyocardiumA Histopathological Evaluation After Six Months. AMA Arch Surg. 1956;73(2):187-191. doi:10.1001/archsurg.1956.01280020001001