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December 1956

Ventricular Fibrillatiion During HypothermiaTolerance of the Hypothermic Dog Heart to Ventricular Fibrillation

Author Affiliations

U. S. Army (Res.); U. S. Army; U. S. Army
Department of Experimental Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington 12, D. C.

AMA Arch Surg. 1956;73(6):985-988. doi:10.1001/archsurg.1956.01280060085019

In a previous report from this laboratory,1 it was shown that normal dogs undergoing hypothermia tolerated varying periods of ventricular fibrillation up to two hours with defibrillation and recovery. The dogs were resuscitated by cardiac massage, during which time the temperature of the heart was increased by warm saline irrigation of the thoracic cavity, followed by electric shock applied to the heart. Since the hearts of these animals were essentially normal, and since any clinical application of accepting or inducing ventricular fibrillation for cardiac surgery would be carried out on abnormal hearts, this project was extended to determine the tolerance of the abnormal dog heart to ventricular fibrillation during hypothermia.

Methods  Adult healthy mongrel dogs weighing from 9 to 27 kg. were used. Two types of abnormal hearts were produced. The first, a cyanotic preparation, was created finally by the method of Watkins.2 Initially, other methods of producing

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