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Article
February 1957

Healing of Infected Wounds Treated with Human Plasmin and HyaluronidaseDébridement and Healing of Infected Wounds, Several with Metallic Foreign Bodies

Author Affiliations

New York
Associate Professor of Clinical Surgery, Cornell University School of Medicine, and Associate and Head of the Enzyme Research Section, Sloan-Kettering Institute.; From Andre and Bella Meyer Physiology Laboratory (Enzyme Research Section) of the Sloan Kettering Institute for Cancer Research and the Memorial Center for Cancer and Allied Diseases.

AMA Arch Surg. 1957;74(2):207-214. doi:10.1001/archsurg.1957.01280080057009
Abstract

Enzyme therapy of infected wounds and ulcerating lesions is a rapidly developing field, in which there is great promise. It is said that John Hunter used crude pancreatic enzymes in the treatment of wounds. The maggot treatment of dirty chronic infected wounds and osteomyelitis cavities was undoubtedly effective because of proteolytic enzymes secreted by the maggots.1 The modern methods of enzyme treatment using purified materials have been developed only in recent years.2 Papain3 was used as long ago as the First World War for cleansing of infected burns and dirty wounds but was abandoned because of the severe irritation it caused. It was with streptokinase and streptodornase4 that the first well-controlled studies of this type of therapy were made.5-8 Trypsin, a proteolytic enzyme obtained from the pancreas, is a stronger digestive enzyme, which has been used with success in debridement.9-11 Bovine plasmin (fibrinolysin) has

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