February 1957

The Homograft Rejection Mechanism

Author Affiliations

From the Division of Plastic Surgery, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine.

AMA Arch Surg. 1957;74(2):238-244. doi:10.1001/archsurg.1957.01280080090014

Introduction  The general purpose of this study was to learn more about the homograft rejection mechanism. We realized that previous studies were not clear as to the morphology and dynamics of grafting. Only by animal study can the variables be sufficiently controlled to draw reliable conclusions.We selected a small mammal because of known similarities to the human, in giving birth to living young and in the existence of species individuality.The mouse seemed ideal, since the development of inbred strains has given us individuals that are so nearly identical, genetically, that tissues may be transferred between individual isogenic mice with the same success encountered when autografting in the human. Recently, Eichwald8 has shown that certain isogenetic grafts from males onto females will not "take" as consistently as autografts, but in general these strains are comparable in genetic similarity to human identical twins. Thus the isograft in the mouse

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