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Original Article
April 1957

Effect of Hepatic Arterial Ligation on Hepatic Blood Flow and Related Metabolic Function

Author Affiliations

Iowa City

From the Department of Physiology and Cardiovascular Laboratory, State University of Iowa College of Medicine.

AMA Arch Surg. 1957;74(4):565-570. doi:10.1001/archsurg.1957.01280100083014

The presence of collateral arterial circulation to the liver has been deemed essential to the survival of animals subjected to hepatic arterial ligation. Such channels to the liver have been reported to originate from the diaphragm and pancreaticoduodenal area as well as through small arteries coursing along the inferior vena cava and common bile duct. Tanturi1 has stated that these channels cannot provide enough blood to account for the animal's survival and has occasionally found animals without collateral circulation. Markowitz2 has commented that there is nothing about the anatomy of the liver which makes the hepatic artery essential to an animal's survival. This study was undertaken in an attempt to determine the pattern of development of collateral arterial circulation and to study hepatic blood flow and related metabolic functions in animals whose liver has been deprived of its highly oxygenated blood supply.

Methods  The hepatic arterial supply to

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