The presence of collateral arterial circulation to the liver has been deemed essential to the survival of animals subjected to hepatic arterial ligation. Such channels to the liver have been reported to originate from the diaphragm and pancreaticoduodenal area as well as through small arteries coursing along the inferior vena cava and common bile duct. Tanturi1 has stated that these channels cannot provide enough blood to account for the animal's survival and has occasionally found animals without collateral circulation. Markowitz2 has commented that there is nothing about the anatomy of the liver which makes the hepatic artery essential to an animal's survival. This study was undertaken in an attempt to determine the pattern of development of collateral arterial circulation and to study hepatic blood flow and related metabolic functions in animals whose liver has been deprived of its highly oxygenated blood supply.
The hepatic arterial supply to
HORVATH SM, FARRAND EA, LARSEN R. Effect of Hepatic Arterial Ligation on Hepatic Blood Flow and Related Metabolic Function. AMA Arch Surg. 1957;74(4):565-570. doi:10.1001/archsurg.1957.01280100083014