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This exhibit is based primarily on personal experience with adenomas of the colon and rectum. Although some aspects of this problem have no ready solution, a relatively uniform pattern is nevertheless discernible.
A special word about biopsy of adenomas: We are against fractional biopsy because the character of the interior of the body or the base of the lesion is not usually revealed. We practice "total biopsy," or the removal of the entire polyp at its base in one piece or in several large segments, which has real diagnostic and at the same time therapeutic value. We maintain great reservations about any diagnosis in adenomas that is based on frozen section technique, since the best pathologists can be deceived in both directions.
The criteria for the early diagnosis of early cancer in adenomas, particularly that of the noninvasive variety, differ enormously with the experience and perhaps the philosophy of the
TURELL R. Adenomas of the Colon and Rectum. AMA Arch Surg. 1957;74(4):649-660. doi:10.1001/archsurg.1957.01280100167030