In recent years, reports continue to appear in the literature indicating the favorable features of the nonoperative treatment of perforated peptic ulcer.14,17 In several series so reported, the mortality has been equal to that of several of the series in which primary closure of the perforated ulcer was accomplished.17 However, to date, in the larger reported nonoperative series, no one has reported a group without mortality, as is currently noted in several series of consecutive operative cases.
In recent years, as a result of the many advances made in surgery, anesthesiology, and antibiotic and electrolytic therapy, the mortality in acute perforated peptic ulcer has shown a decided decline.5,6,9,10,14,17 In fact, many series have been reported in which no deaths occurred if surgery was performed within 12 to 15 hours. Prior to 1950, the mortality in the group treated by the operative method varied from 1.1% to 30%,
PALUMBO LT, SMITH AN, CLAMAN MA, SKINNER HL. Acute Perforated Peptic UlcerResults of Operative Treatment. AMA Arch Surg. 1957;75(5):843-846. doi:10.1001/archsurg.1957.01280170153051