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January 1958

Hemorrhagic Telangiectasia (Rendu-Osler-Weber Disease)Report of Case Associated with Severe Repeated Gastrointestinal Hemorrhage

Author Affiliations

From the Department of Surgery, Cook County Hospital, and the Vaughn Medical Group.; Clinical Professor of Surgery, Stritch School of Medicine of Loyola University; Professor of Surgery, Cook County Graduate School of Medicine; Attending Surgeon, Cook County Hospital; Attending Surgeon, Mercy Hospital (Dr. Vaughn). Clinical Instructor in Surgery, Stritch School of Medicine of Loyola University; Associate in Surgery, Cook County and Columbus Hospitals; Junior Attending Surgeon, Mercy Hospital (Dr. White). Surgical Resident, Cook County Hospital (Dr. McCoy).

AMA Arch Surg. 1958;76(1):167-170. doi:10.1001/archsurg.1958.01280190169033

Multiple, usually hereditary, hemorrhagic telangiectasis (hemorrhage telangiectasia) is a rare entity, although well recognized clinically in the last 35 years. The disease was first reported by Legg,1 who in 1876 recorded the first case of inherited telangiectasis involving both the skin and the mucous membranes. However, little interest was aroused in the disease until, in 1896, Rendu2 described a patient with repeated attacks of epistaxis who later displayed telangiectases of the skin of the face and mucous membranes of the mouth. Osler,3 in 1901, reported three cases of the disease, the first report in this country, and in 1907 Weber4 reported the disease, also called the Rendu-Osler-Weber syndrome.

The purpose of our case report is to put the physician and surgeon, when confronted with a case of severe gastrointestinal bleeding, on the alert to include, in the differential diagnosis, the possibility of multiple hemorrhagic telangiectasis.


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