March 1959

Adenocarcinoma of the Jejunum in Nonspecific Granulomatous Enteritis

Author Affiliations

New York
From the Divisions of Medicine, Laboratories (Pathology), and Diagnostic Radiology, Montefiore Hospital.; Attending Physician, Medical Division, Montefiore Hospital, and Assistant Clinical Professor of Medicine, Columbia University College of Physicians and Surgeons (Dr. Weingarten). Adjunct Attending Physician, Medical Division, Montefiore Hospital, and Clinical Instructor in Medicine, Albert Einstein College of Medicine of Yeshiva University (Dr. Parker). Resident in Pathology ( Division of Laboratories), Montefiore Hospital (Dr. Chazen). Chief, Division of Diagnostic Radiology, Montefiore Hospital, and Clinical Professorof Radiology, New York University College of Medicine (Dr. Jacobson).

AMA Arch Surg. 1959;78(3):483-489. doi:10.1001/archsurg.1959.04320030127021

Nonspecific granulomatous ileitis, as a distinct entity, was described for the first time by Crohn, Ginzburg, and Oppenheimer in 1932.1 References to this disease are made in the literature as far back as 1769, by Morgagni,2 and in 1913 by Dalziel,3 and in 1923 by Moshcowitz and Wilensky.4 The disease is not uncommon, with Marshak and Wolf5 reviewing 750 cases from the Mount Sinai Hospital in New York in 1955 and Van Patter, Bargen, et al.6 reporting on 600 cases from the Mayo Clinic in 1954. The incidence of malignancy in the small bowel in nonspecific granulomatous enteritis is extremely low. The first case reported was that of Ginzburg et al. in 1956,7 with an adenocarcinoma seen in the jejunum and multiple metastases to the liver. The inflammatory disease in the small bowel appeared to have been present for 15 years, from the

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