The syndrome commonly known as lower nephron nephrosis has been observed to be associated with a wide variety of disease processes. Many theories as to its etiology have been proposed, but none has been proved. Oliver1 has stated:
And yet amidst all this elaboration of hypothesis and semantic confusion, the syndrome stands clearly outlined as the most important of the acute disturbances of the urinary system. This place it maintains, not only by the frequency of its occurrence and the gravity of its ultimate effects, but more importantly by the remarkably protean aspect of its origin, it would seem that almost any clinical situation—trauma, malarial infection, obstetrical accident, transfusion reaction, post-operative complication or intoxication may end with its manifestation of renal failure. There must be, therefore, some pathogenetic unity behind this screen of functional, pathological and clinical diversity.
It is the purpose of this report to present evidence that
HARDAWAY RM, McKAY DG. Changes in the Dog Kidney Produced by Incompatible Blood Transfusion. AMA Arch Surg. 1959;78(4):565-573. doi:10.1001/archsurg.1959.04320040061017