The importance of maintaining a more or less constant blood volume, during and after total body perfusion, is self-evident. This report concerns the results of measurements of various parameters which affect blood volume. The measurements were obtained in 50 consecutive patients who were treated surgically for a variety of congenital and acquired cardiac defects. In all instances, the Clark bubble pump-oxygenator1,2 was used to maintain extracorporeal circulation during surgery.
Radioiodinated serum albumin (RISA) blood volumes were measured in 41 patients. These patients received 5 to 10 drops of a saturated solution of potassium iodide for three days prior to study in order to block the uptake of I131 in the thyroid gland. A blood volume estimation was undertaken soon after the patient was anesthetized, and this was used as the control value. A second blood volume determination was undertaken one hour after the completion of the cardiotomy,
KAPLAN S, EDWARDS FK, HELMSWORTH JA, CLARK LC. Blood Volume During and After Total Extracorporeal Circulation. AMA Arch Surg. 1960;80(1):31-38. doi:10.1001/archsurg.1960.01290180033004