A mass of experimental and clinical data has appeared in the literature in attempts to explain the factors involved in the production of gastric hyperacidity and methods for its control. Various factors—nervous, hormonal, chemical, and mechanical—are recognized as predominating in individual instances. Variations in gastric acidity have been brought about by aggravating or diminishing the activity of each or all of these factors through nutrition, drugs, and surgery and roentgen rays. Studies to determine the effects of the component parts of gastric secretion and the sites of secretion upon acid concentrations have provoked ingenious experiments. Estimations of the rate of secretion; of the chloride, sodium, nitrogen and potassium concentrations, and of the composition of an isotonic buffer containing secretion which is similar to blood plasma and acts by neutralization and dilution of the gastric contents have concerned many investigators.
Varied but generally good results have followed attempts to eliminate the
McCULLOUGH JY. The Effect of Roentgen Therapy upon Gastric AcidityClinical and Experimental Studies. AMA Arch Surg. 1960;80(2):226-233. doi:10.1001/archsurg.1960.01290190046010