Recent introduction of techniques for isolating a region of the body and temporarily perfusing the localized area with oxygenated blood containing a chemotherapeutic agent3-5 has given impetus to the treatment of extremity malignancies. While the disposable bubble oxygenator commercially available for this purpose * is apparently adequate, our laboratory experiments with this apparatus have been complicated by excessive depositions of fibrin within the oxygenator and by oxygen bubble emboli in the arterial flow.
Our previous favorable experience with the rotating disc oxygenator led us to evaluate the efficiency of this machine when used in localized perfusions. Early in our laboratory trials with the technique it became obvious that high flows were neither necessary nor desirable. With the normal circulation intact, the major portion of the cardiac output goes to essential organs, and small blood flows suffice in the extremities. The body as a whole utilizes proportionately more oxygen than resting
CARTWRIGHT RS, PALICH WE. An Oxygenator for Isolation-Perfusion in the Treatment of Cancer. AMA Arch Surg. 1960;80(3):506-507. doi:10.1001/archsurg.1960.01290200150027