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May 1960

An Experimental Study of Side-to-Side Pancreaticojejunostomy After Ductal Obstruction

Author Affiliations

Rochester, Minn.
Abridgment of thesis submitted by Dr. Carnevali to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Surgery.; Fellow in Surgery, Mayo Foundation (Dr. Carnevali); Section of Surgery (Dr. ReMine); Section of Surgical Pathology (Dr. Dockerty); Section of Biochemistry (Dr. Bollman), and Section of Surgical Research (Dr. Grindlay), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

AMA Arch Surg. 1960;80(5):774-787. doi:10.1001/archsurg.1960.01290220066010

The purpose of this study was to evaluate in dogs the surgical procedure of side-to-side pancreaticojejunostomy. This operation involves longitudinal division of the main pancreatic duct along with the overlying parenchyma, and establishment of pancreatic drainage by anastomosis of the cut edges of the pancreas to the side of a Roux-Y segment of jejunum. First, because it involves extensive dissection and manipulation of the gland, we wished to determine whether the procedure itself was injurious to the pancreas, or too formidable in terms of mortality. Second, we wished to know whether, in the presence of pancreatitis, animals could tolerate the procedure, and whether it produced a beneficial effect on the course of the disease.

The stimulus for this study resulted largely from the report of Puestow and Gillesby1 concerning the use of side-to-side drainage in a limited number of patients with chronic relapsing pancreatitis. The procedure was based on

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