Patients ill of acute thrombophlebitis in the lower extremities frequently are treated by the administration of anticoagulant drugs for one to four weeks, by operative venous ligation, or by a combination of these methods. Therapy by bed rest, elevation, and elastic supports alone is not often recommended because ligational and anticoagulant therapeutic techniques are assumed to reduce the incidence of thromboembolic complications and hasten recovery from the illness.
This study was undertaken in an attempt to determine whether or not therapy for thrombophlebitis including an anticoagulant regimen is superior to the use of elastic supports, elevation of the leg, and bed rest without specific anticoagulant drug therapy.
The case records reviewed were those of patients with venous thrombosis or thrombophlebitis in the veins of the lower extremities treated in the Barnes Hospital between Jan. 1, 1954, and Jan. 1, 1958. Patients dying of pulmonary embolus or other cause were
BUTCHER HR. Anticoagulant Drug Therapy for Thrombophlebitis in the Lower ExtremitiesAn Evaluation. AMA Arch Surg. 1960;80(5):864-875. doi:10.1001/archsurg.1960.01290220156020