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February 1961

Skeletal Metastases in Cystosarcoma PhylloidesA Case Report and Review

Author Affiliations

Associate Attending Surgeon, Ingalls Memorial Hospital, Harvey, Ill.; From the Department of Surgery, Michael Reese Hospital and Medical Center, Chicago.

Arch Surg. 1961;82(2):275-280. doi:10.1001/archsurg.1961.01300080103006

The purpose of this paper is to report a case of skeletal metastases in cystosarcoma phylloides and to review 275 cases collected from the literature with particular reference to incidence of such malignant variants. Although a few cases with skeletal metastases have been reported, the subject itself has never been given separate consideration.

Cystosarcoma phylloides is a variety of fibroepithelial tumor related to the adenoma of the breast.2 Johannes Müller6 classified this tumor in 1838 as a separate entity from adenofibroma. Since then the wide morphological variations of the tumor have been recognized, and the concepts of its behavior and criteria of its pathological diagnosis have undergone considerable changes.

Report of Case  A 31-year-old pregnant Negro woman was seen in the prenatal clinic 3 months prior to term on March 1, 1957. Routine examination at this visit revealed a mass of the right breast. Her previous medical history

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