The development of strains of organisms resistant to antibiotics often constitutes a serious problem in surgery. With the present use and abuse of antibiotics, the continuing emergence of resistant strains may be confidently predicted. Furthermore, toxic side-effects of certain antibiotics3,4 are a limiting factor in therapy.
The development of isolated perfusion techniques for the treatment of malignancies with systemically toxic drugs1,6 suggested the extension of this technique to localized infections that were resistant to systemic or topical antibiotic therapy.
Beginning in 1957, studies were undertaken to determine in animals safe dosages of various antibiotics administered by these techniques, and subsequently 8 patients were treated. This report is concerned with experimental and clinical studies of regional perfusion of areas of chronic infections.
Methods and Materials
The hind limb of a dog was used for determination of drug dosages.7,8 After placement of a tourniquet, the femoral artery and vein
RYAN RF, REEMTSMA K, BEDDINGFIELD GW, CREECH O, WICKSTROM J. Regional Perfusion with AntibioticsMethod for the Treatment of Chronic Infections. Arch Surg. 1961;82(3):482-487. doi:10.1001/archsurg.1961.01300090152030