Since the work of Klopp,5,6 Creech,1-4 and others,7-10 perfusion has attracted wide attention as a method of treating patients with certain types of malignant neoplasms. In The University of Texas M. D. Anderson Hospital and Tumor Institute, 167 perfusions were performed for 131 patients during the 2½ years between Dec. 1, 1957, and June 1, 1960. The procedure has been employed as a means of studying cancer in the human subject, and for testing the effects of chemotherapeutic agents upon tumors, as well as for the treatment of patients. Even as a therapeutic measure, however, it is still regarded as largely experimental, in that sufficient time has not elapsed to permit a proper estimate of its value.
—Regional perfusion, especially of the distal extremities, affords an excellent opportunity for studying the responses of tumors to chemotherapeutic agents without endangering the lives of patients, and thus
STEHLIN JS, CLARK RL. Chemotherapy for Cancer by Regional Perfusion. Arch Surg. 1961;83(2):196-202. doi:10.1001/archsurg.1961.01300140038006