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April 1962

Serum Dextran ClearanceStudies in Normal and Acutely Irradiated Dogs

Author Affiliations

From the Departments of Surgery and Radiology, Hahnemann Medical College.

Arch Surg. 1962;84(4):454-461. doi:10.1001/archsurg.1962.01300220078013

The aim of this investigation has been to evaluate the efficacy of using dextran as a plasma expander during a potential military or civilian mass casualty situation in which individuals would suffer both blood loss and the effects of varying levels of whole-body irradiation.

As an initial approach to the problem on a laboratory basis, the rates of clearance of a standard dextran preparation from the sera of normal control and acutely irradiated dogs have been determined.

Materials and Methods  Twenty-four mongrel dogs (male and female) weighing between 9.5 and 18.5 kg. were selected for the study and placed on a stabilization regimen which consisted of (1) deworming procedures, using 5 cc. tetrachloroethylene treatments, (2) maintenance on a diet of Purina Kibbled Meal and beef tongue, and (3) periodic determinations of hemoglobin, hematocrit, white blood cell counts (differentials), and total plasma protein levels. The dogs were then arbitrarily divided into

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