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May 1962

Regression of Pulmonary Metastases of a Breast CancerReport of a Case of Spontaneous and Temporary Regression After Radical Mastectomy

Author Affiliations

Breast Service, Dept. of Surgery, Roswell Park Memorial Institute.

Arch Surg. 1962;84(5):574-577. doi:10.1001/archsurg.1962.01300230090017

Clinical observations suggestive of host defense against cancer are numerous. Among them, the most intriguing phenomenon is the "spontaneous regression" of metastatic disease after removal of the primary tumor. Spontaneous disappearance of a pulmonary metastasis of a carcinoma of the kidney following nephrectomy has been reported by several authors.1-3 It is also known that pulmonary metastases of chorio-carcinoma may disappear after removal of the primary tumor.4

There has been no report in the literature of spontaneous regression of pulmonary metastases of a breast cancer after radical mastectomy. The case reported here also illustrates some interesting features of the clinical behavior of a hormone-dependent mammary cancer.

Report of Case  The patient was first seen at the Roswell Park Memorial Institute on Oct. 10, 1956, at the age of 65. She was referred here for the diagnosis and treatment of a mass in the right breast and axilla, a mass

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