July 1962

Hepatic Function After Canine Liver Transplantation

Author Affiliations

From the Surgical and Radioisotope Services, Veterans Administration Research Hospital and Northwestern University Medical School.

Arch Surg. 1962;85(1):157-165. doi:10.1001/archsurg.1962.01310010161022

Homotransplanted canine livers can survive in recipient dogs for as long as 3 weeks.10,11 Evaluation of liver function and other tissue metabolism can be made during this time. Studies of this kind may lead to a better understanding of the homograft rejection mechanism.

Previous histological and biochemical studies in dogs following total homotransplantation of the liver have shown a marked proliferative cellular response in the organs and a progressive obstructive jaundice pattern in the blood. Total serum protein and albumin levels as well as albumin-globulin concentration showed no marked alterations as determined by ordinary laboratory methods.11 When paper electrophoretic analyses were done, a fall in albumin and a rise in α2-globulin were most characteristic.10 The availability of radioisotopic techniques for studying plasma protein metabolism prompted the present study with 2 objectives in mind: (1) to determine the rate at which the homotransplanted liver synthesizes individual

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